Construction

Citizens Branch Manager (ESSEX JUNCTION)

Description At Citizens, we’re focused on relationship-building and delivering exceptional customer experiences through every interaction. By fostering deep and lasting relationships, we drive customer loyalty while advancing our strategic goals to acquire, retain, and grow the business. As a Branch Manager (BM) , you will lead your team in exceeding customer expectations, nurturing relationships that drive long-term success. In this role, you’ll spearhead branch performance, sales growth, and an outstanding colleague and customer experience. By leveraging inspirational leadership, collaborative partnerships, and sound operational practices, you will create and sustain a strong customer-centric culture. As both a leader and coach, you’ll help your team achieve individual and collective performance and sales goals through innovative solutions that address customer needs and deliver product and service value. A successful BM thrives in a digital-first environment, showcasing the seamless accessibility of mobile and online banking platforms to customers. You’ll play a pivotal role in building a diverse talent pipeline, developing your colleagues to meet evolving business needs, and prioritizing their performance and growth. With a focus on continuous learning, you’ll implement coaching plans that inspire your team to achieve personal and branch-wide goals. To succeed, you must effectively communicate business priorities in a way that energizes and empowers your colleagues to execute with confidence. As the branches execution and outcomes owner, you’ll combine financial acumen with strategic insights to guide decision-making and deliver results. Leading by example, you will direct all colleague and sales activities to ensure key targets are not only met but exceeded. As a visible and engaged brand ambassador, you will connect with the local community to cultivate new customer relationships and deepen existing ones. Qualifications, Education, Certifications and/or Other Professional Credentials Required Qualifications High School diploma or equivalent required Leadership experience, with proven ability to coach and develop to drive sales excellence, ensure the delivery of world-class customer service, and operational integrity in a high-volume branch environment 4 years sales management experience in Retail or Branch Banking environment Successful record of managing objectives in meeting sales goals, deadlines and branch goals in a profit and loss environment Drive an exceptional customer experience validated through customer satisfaction surveys Maintain strong partnerships with community & civic organizations Successful candidate must meet and comply with all requirements set forth in the SAFE Act, including, but not limited to successful completion of the required background checks and obtaining a unique identifier from the NMLS Preferred Qualifications Associate’s or Bachelor’s degree preferred Retail banking Talent sourcing & assessment Hours and Work Schedule Hours per Week: 40 Work Schedule: Varies with branch needs and may include weekends and evenings Pay Transparency The salary range for this position is $81,000 - $111,000 per year, plus an opportunity to earn additional incentive earnings. Actual pay is based on various factors including but not limited to the budget, work location, and relevant skills and experience. We offer competitive pay, comprehensive medical, dental and vision coverage, retirement benefits, maternity/paternity leave, flexible work arrangements, education reimbursement, wellness programs and more. Note, Citizens’ paid time off policy exceeds the mandatory, paid sick or paid time-away policy of every local and state jurisdiction in the United States. For an overview of our benefits, visit https://jobs.citizensbank.com/benefits . Some job boards have started using jobseeker-reported data to estimate salary ranges for roles. If you apply and qualify for this role, a recruiter will discuss accurate pay guidance. Equal Employment Opportunity Citizens, its parent, subsidiaries, and related companies (Citizens) provide equal employment and advancement opportunities to all colleagues and applicants for employment without regard to age, ancestry, color, citizenship, physical or mental disability, perceived disability or history or record of a disability, ethnicity, gender, gender identity or expression, genetic information, genetic characteristic, marital or domestic partner status, victim of domestic violence, family status/parenthood, medical condition, military or veteran status, national origin, pregnancy/childbirth/lactation, colleague’s or a dependent’s reproductive health decision making, race, religion, sex, sexual orientation, or any other category protected by federal, state and/or local laws. At Citizens, we are committed to fostering an inclusive culture that enables all colleagues to bring their best selves to work every day and everyone is expected to be treated with respect and professionalism. Employment decisions are based solely on merit, qualifications, performance and capability. Why Work for Us At Citizens, you'll find a customer-centric culture built around helping our customers and giving back to our local communities. When you join our team, you are part of a supportive and collaborative workforce, with access to training and tools to accelerate your potential and maximize your career growth Background Check Any offer of employment is conditioned upon the candidate successfully passing a background check, which may include initial credit, motor vehicle record, public record, prior employment verification, and criminal background checks. Results of the background check are individually reviewed based upon legal requirements imposed by our regulators and with consideration of the nature and gravity of the background history and the job offered. Any offer of employment will include further information.

  • Pinewood, VT

  • no content

Associate Medical Director, Clinical Science, GI2 TAU (CAMBRIDGE)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Associate Medical Director, Clinical Science, GI2 TAU in our Cambridge, MA office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission. ACCOUNTABILITIES: Represents Clinical Science on Project or Clinical Teams and may serve as the Clinical Science leader on these teams Supports the Global Project Team to ensure that the clinical team activities are aligned with the global strategy Contributes to the overall Asset Strategy by supporting the development of the Clinical Development Plan, leads the development of Clinical Protocols and other documents needed for CDP and study execution and regulatory submissions. Recommends scope, complexity and size, and influences the budget of all aspects of a study Ongoing work output will involve continual critical evaluation of the development strategy to maintain a state-of-the-art development plan that is competitive and consistent with the latest regulatory requirements, proactive identification of challenges, and development of contingency plans to meet them. Recommends high impact global decisions. Responsible for monitoring and interpreting data from ongoing internal and external studies, assessing the medical and scientific implications and making recommendations that impact regional and global development such as “go/no go” decisions or modification of development plans or study designs that may have a significant impact on timelines or product labeling. A significant error in judgment may result in loss of approvability and/or commercial viability of a product. Synopsis / Protocol Development, Study Execution, & Study Interpretation Oversees Clinical Science department activities relating to the preparation/ approval of Synopses, Protocols and the conduct of clinical studies. Serves as an advisor to other clinical scientists involved in these activities and is accountable for the successful design and interpretation of clinical studies. Presents study conclusions to Management and determines how individual study results impact the overall compound strategy. Interprets data from an overall scientific standpoint as well as within the context of the medical significance to individual patients. Trial Medical Monitoring Responsible for medical monitoring activities, assessing issues related to protocol conduct and/or individual subject safety. Assesses overall safety information for studies and compound in conjunction with Pharmacovigilance. Oversees non-medical clinical scientists with respect to assessment of these issues. Makes final decisions regarding study conduct related to scientific integrity External Interactions Directs interactions with key opinion leaders relevant to assigned compounds and therapeutic area. Provides leadership in meetings and negotiations with key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g. briefing reports), materials used for meeting presentations, and formal responses to communications received from the regulatory organizations or opinion leaders Leads incorporation of advice/recommendations received into the design of clinical studies and programs as appropriate. Due Diligence, Business Development and Alliance Projects Responsible for evaluation of potential business development opportunities, conducts due diligence evaluations assessing scientific, medical, and development feasibility, evaluating complete or ongoing clinical trials, assessing regulatory interactions and future development plans. For ongoing alliance projects, will interface with partner to achieve Takeda’s strategic goals while striving to maintain good working relationship between Takeda and partner. Leadership, Task Force Participation, Upper Management Accountability Interacts directly with research division based on pertinent clinical and development expertise. Represents clinical science on high impact/priority task forces across the organization or external to the company. Hires, manages, mentors, motivates, empowers, develops and retains staff to support assigned activities. EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: MD or internationally recognized equivalent plus 3 years of clinical research experience within the pharmaceutical industry, CRO health-related consulting company, or biomedical/clinical experience within academia (or a combination of afore mentioned). Subspecialty in Hepatology or Immunology highly preferred. Experience and knowledge of alpha-1 antitrypsin deficiency a plus. Phase 3 Clinical Trial experience preferred Previous experience successfully leading matrix teams preferred. Management experience preferred Skills Superior communication, strategic, interpersonal and negotiating skills Ability to proactively predict issues and solve problems Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams Diplomacy and positive influencing abilities Knowledge Therapeutic area knowledge relevant to mechanisms of action of compounds in remit Regional/global Regulatory requirements GCP/ICH Emerging research in designated therapeutic area Travel requirements Ability to drive to or fly to various meetings or client sites, including overnight trips. Some international travel may be required. Requires approximately 15 - 25% travel This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy. Discover more at takedajobs.com No Phone Calls or Recruiters Please. LI-JV Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: USA - MA - Cambridge U.S. Base Salary Range: $198,500.00 - $311,850.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

  • Cambridgeport, MA

  • no content

AIRx Director, Computational & AI Biologics Design Lead (BOSTON)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Director, Computational & AI Biologics Design Lead Takeda Research is constructing a Lab of Tomorrow built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and Discovery Automation & Robotics (DAR). AIRx will have a group of a dedicated group of experienced biologic drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI-powered operating models for large molecule discovery and deliver candidates to the clinic at industry leading speed and success rates. Purpose Reporting to the Head of AIRx, the Computational & AI Biologics Design Lead sits at the scientific heart of the Takeda Boston (TBOS) Large Molecule Pod. As part of the AIRx team, this role serves as a strategic computational leader, driving in silico biologics design and shaping how AI-enabled biologics discovery is executed for select programs. This role drives in silico biologics design, applies generative AI and structure-informed methods to antibody and large-molecule programs, and connects Takeda’s internal AI/ML platform capabilities to the day-to-day decisions of a fast-moving drug-hunting team. In addition, the role defines decision frameworks and scientific standards that influence candidate prioritization, progression, and overall portfolio direction. Proposals from this role directly shape what gets engineered, what gets deprioritized, and what ultimately reaches the clinic. The role is deeply hands-on, with a mandate to operate with urgency and independence while remaining tightly integrated with biology, protein engineering, and translational science colleagues across the pod. Key Accountabilities 1. In Silico Biologics Design for Pod Programs Define and drive the computational design strategy across the pod’s large-molecule programs, including antibody, VHH, and multispecific or fusion formats, from early format selection through lead optimization. Design and prioritize molecular candidates using generative AI/ML and computational modeling approaches Serve as a scientific advisor to pod leadership on computational design decisions, influencing program direction and key trade-offs Partner closely with the Biologics Discovery Lead to translate computational proposals into testable engineering priorities; challenge and be challenged on scientific assumptions in equal measure. Integrate structural biology data into design strategies to inform format selection, epitope targeting, and interface optimization. Oversee virtual screening, binding affinity prediction, and developability risk assessment for candidate sequences; provide ranked shortlists with quantified uncertainty to the pod. Establish and improve approaches to accelerate lead optimization by compressing DMTA cycles through AI-guided design, with the goal of achieving the target candidate profile in fewer rounds. Collaborate with translational and DMPK scientists to model PK/PD behavior, TMDD, and species cross-reactivity in silico, informing study design and reducing in vivo cycle time. 2. AI/ML Platform Interface and Data Strategy Serve as the pod’s primary computational interface to Takeda’s AI/ML research platform; evaluate and benchmark new AI design tools against the pod’s specific biologics modalities and program needs. Define and steward data requirements for AI model training within the pod: structure data return from experimental campaigns, annotation standards, and integration with Takeda’s data infrastructure. Contribute to building and curating AI/ML training datasets from pod experimental outputs to enable continuous model improvement. Guide development and refinement of computational workflows to enable pod scalability, speed and reproducibility across the DMTA cycle; document methods to support cross-pod learning. 3. Pod Integration and Scientific Operations Act as a hands-on computational authority within pod governance: prepare and present in silico analyses for PRC reviews, design review boards, and candidate declaration milestones. Ensure computational requirements are integrated early in external experimental campaigns to maximize data return value. Interface with Takeda’s discovery automation capabilities to define assay and data readout specifications for pod programs entering automated workflows when applicable. 4. Scientific Leadership and External Engagement Maintain deep subject-matter expertise by staying current with advances in AI for biologics design and structure prediction; translate emerging capabilities into actionable proposals for the pod. Identify and translate relevant external innovations into opportunities that enhance pod capabilities and programs Represent Takeda’s computational biologics capabilities in interactions with external partners, at conferences, and in the scientific community; contribute to publications and IP filings as appropriate. Provide scientific mentorship within the AIRx context and help shape computational biologics practices across the broader research organization. Qualifications & Competencies Expected Requirements: PhD in Computational Biology, Bioinformatics, Structural Biology, Computer Science, or a closely related discipline. 10 years of drug discovery experience with a demonstrated track record of computational impact on large-molecule or biologics programs; industry experience strongly preferred. Deep expertise in antibody and protein sequence, structure, and function modeling, with proficiency in generative or predictive AI frameworks applied to biologics design. Broad proficiency in computational tools relevant to biologics, spanning structural analysis, molecular simulation, developability prediction, and bioinformatics. Strong coding skills (Python required); experience building and deploying ML models in a drug discovery context; familiarity with cloud-based compute and MLOps practices. Demonstrated ability to operate as both a technical individual contributor and a cross-functional scientific partner in a fast-paced, program-driven environment. Versatile communicator: able to present complex computational findings to biologists, clinical scientists, and senior leadership with clarity and scientific rigor. Preferred Experience with multispecific antibody formats and the associated engineering, developability, and PK/PD considerations. Experience integrating physics-based modeling with deep learning approaches to improve prediction accuracy and generalization. Prior experience defining data requirements and governance for AI/ML platform development across multiple programs or sites. Experience operating within or alongside an external AI design partner environment, including co-design workflows and campaign-level data return. Track record of contributing to IND-enabling programs; familiarity with candidate declaration criteria and biologics CMC considerations. ADDITIONAL INFORMATION The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $177,000.00 - $278,080.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and

  • Cambridgeport, MA

  • no content

Citizens Teller - Part Time (WILLISTON)

Description Starting Salary: $21 / hour and up As a Citizens Teller - YOU make a real difference for our customers and the branch team. What you'll do You’ll greet our customers in our lobbies. You’re comfortable enough with technology to demonstrate how to use our mobile app, or our ATMs, to complete simple transactions. You’ll create amazing experiences for our customers, looking for opportunities to help them achieve their financial goals by providing personalized advice and solutions that meet their needs, and connect them to our Bankers for the next step. Your knowledge of Citizens products and benefits will educate customers, and allow you to effectively respond to questions and/or concerns. All financial policies and procedures will be followed, including proper cash handling, state and local laws and regulations. What you'll get Meaningful work & relationships – Help customers with important financial decisions that impact their lives like building a business, buying a house, paying for school or helping them realize their long-term financial goals. Colleagues and leadership listen to your ideas and feedback. Commitment to community – Give back with 8 hours of paid time off annually for volunteering, separate from regular PTO, and have your donations to eligible 501(c)(3) organizations matched, up to $1,000 annually. Career opportunities, reward, and upskilling – See your hard work rewarded with promotions and opportunities to grow your career through training, coaching, career planning and development resources that enable you to branch off in any direction your talents and interests take you. Exceptional benefits – Receive comprehensive health care coverage, including medical, dental and vision plans, a 401K with corporate match, tuition assistance, mental health and wellbeing programs, discounts on student loan refinancing, and more. Required Qualifications High School degree or GED Minimum of 6 months experience processing transactions (cash and/or digital payments) Minimum of 1 year demonstrated customer experience, recommending and referring products and services to customers Strong listening and communication skills Ability to effectively ask questions and identify needs to enhance and develop a long-term customer relationship Ability to problem solve and provide solutions to customer issues Customer-centric to deliver exceptional service Comfortable with using digital technology to support the delivery of business goals Ability to work branch hours, which can include weekends and evenings Qualified candidates must complete a video interview assessment after applying as the next step, to be completed within 7 days of receiving the link. How to prepare: Set aside 30-45 minutes for the self-guided assessment that includes games and questions. Find a quiet place to record and be camera-ready. You’ll need a smartphone, tablet, or desktop computer with your camera and microphone enabled. You’ll answer questions to share your skills and experience, and bring your personality to the interview. This step accelerates the interview process, moving qualified candidates to hiring manager interview fast. Preferred Skills/Experience 1 year of experience processing transactions (cash and/or digital payments) Motivates others, like teammates, business partners, and specialists, through collaboration Process-oriented, energetic, detail-oriented and ability to multitask effectively Hours & Work Schedule Hours per Week: 20 Work Schedule: Varies with branch needs and may include weekends and evenings Pay Transparency ​ The salary range for this position is $21.00 - $25.48 per hour. Actual pay is based on various factors including, but not limited to, the budget, work location, and relevant skills and experience. ​ We offer competitive pay, comprehensive medical, dental and vision coverage, retirement benefits, maternity/paternity leave, flexible work arrangements, education reimbursement, wellness programs and more. Note, Citizens’ paid time off policy exceeds the mandatory, paid sick or paid time-away policy of every local and state jurisdiction in the United States. For an overview of our benefits, visit https://jobs.citizensbank.com/benefits . Some job boards have started using jobseeker-reported data to estimate salary ranges for roles. If you apply and qualify for this role, a recruiter will discuss accurate pay guidance. Equal Employment Opportunity Citizens, its parent, subsidiaries, and related companies (Citizens) provide equal employment and advancement opportunities to all colleagues and applicants for employment without regard to age, ancestry, color, citizenship, physical or mental disability, perceived disability or history or record of a disability, ethnicity, gender, gender identity or expression, genetic information, genetic characteristic, marital or domestic partner status, victim of domestic violence, family status/parenthood, medical condition, military or veteran status, national origin, pregnancy/childbirth/lactation, colleague’s or a dependent’s reproductive health decision making, race, religion, sex, sexual orientation, or any other category protected by federal, state and/or local laws. At Citizens, we are committed to fostering an inclusive culture that enables all colleagues to bring their best selves to work every day and everyone is expected to be treated with respect and professionalism. Employment decisions are based solely on merit, qualifications, performance and capability. Why Work for Us At Citizens, you'll find a customer-centric culture built around helping our customers and giving back to our local communities. When you join our team, you are part of a supportive and collaborative workforce, with access to training and tools to accelerate your potential and maximize your career growth Background Check Any offer of employment is conditioned upon the candidate successfully passing a background check, which may include initial credit, motor vehicle record, public record, prior employment verification, and criminal background checks. Results of the background check are individually reviewed based upon legal requirements imposed by our regulators and with consideration of the nature and gravity of the background history and the job offered. Any offer of employment will include further information.

  • Williston, VT

  • no content

Senior Medical Director, Clinical Science ,NS TAU- Sleep Medicine (CAMBRIDGE)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Senior Medical Director, Clinical Science Neuroscience, in our Cambridge, MA office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission OBJECTIVES: The Medical Director leads and drives strategy for the overall global (US/EU/Japan) clinical development taking into consideration the medical, scientific, regulatory and commercial issues for assigned Takeda pipeline compounds. Leads a multi-disciplinary, multi-regional, matrix team through highly complex decisions. This individual has the ultimate responsibility for development decisions assessing and integrating the input from various disciplines to create, maintain, and execute a global clinical development plan that will result in the regulatory approval of the assigned compound in multiple regions. Applies clinical/medical decision making to clinical development issues. This individual interacts with and influences TGRD and TPC senior leadership decision-making for the projects by setting strategic direction. Success or failure directly translates to the ability of TGRD to meet its corporate goals and for Takeda to have future commercial products. ACCOUNTABILITIES: Clinical Development team participation and leadership Leads Global (US/EU/Japan) Development Team managing both the US/EU Development Team and the Japan Development Team for a given product. May lead the US/EU Development Teams and represents Clinical Science on the Global (US/EU/Japan) Development Team to ensure that activities are aligned with the global strategy. Establishes and drives Development Team strategy and deliverables producing the Development Strategy, Clinical Development Plan and Clinical Protocols. Recommends scope, complexity and size, and influence the budget of all aspects of a program. Provides continual critical evaluation of the development strategy to maintain a state-of-the-art development plan that is competitive and consistent with the latest regulatory requirements, proactive identification of challenges, and development of contingency plans to meet them. Responsible for high impact global decisions: monitoring and interpreting data from ongoing internal and external studies, assessing the medical and scientific implications, and making recommendations that impact regional and global development such as “go/no go” decisions or modification of development plans or study designs that may have a significant impact on timelines or product labeling. A significant error in judgment may result in loss of approvability and commercial viability of a product. Synopsis / Protocol Development, Study Execution, & Study Interpretation Drives clinical science activities relating to the preparation / approval of synopses, protocols and the conduct of clinical studies. Serves as an advisor to other clinical scientists involved in these activities, and is accountable for the successful design and interpretation of clinical studies. Presents study conclusions to Management and determine how individual study results impact the overall compound strategy. Interprets data from an overall scientific standpoint as well as within the context of the medical significance to individual patients. Trial Medical Monitoring Responsible for medical monitoring activities, assessing issues related to protocol conduct and/or individual subject safety. Assesses overall safety information for studies and compound in conjunction with Pharmacovigilance. Oversees non-medical clinical scientists with respect to assessment of these issues. Makes final decisions regarding study conduct related to scientific integrity. External Interactions Directs activities involved in interactions with regulatory authorities / agencies and clinical development activities undertaken to establish and maintain strong relationships with key opinion leaders relevant to assigned compounds and therapeutic areas. These responsibilities include leadership roles in meetings with the regulatory organizations or key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g. briefing reports), materials used for meeting presentations, and formal responses to communications received from the regulatory organizations or opinion leaders. Lead roles will also be taken on the incorporation of advice / recommendations received into the design of clinical studies / programs as appropriate; accountable to senior leadership for the successful completion of related objectives. Due Diligence, Business Development and Alliance Projects Responsible for identification and evaluation of potential business development opportunities, conduct due diligence evaluations, and development and negotiation of clinical development plans for potential alliances and or in-licensing opportunities. Assesses scientific, medical, and development feasibility, evaluating strategic fit with overall portfolio, evaluating complete or ongoing clinical trials, assessing regulatory interactions and future development plans, interacting with upper management of potential partner/acquisition companies during DD visits and alliance negotiations, and representing clinical science on internal assessment teams in conjunction with TPNA/TPEU/TPC. Serves as clinical contact point for ongoing alliance projects and interface with partner to achieve Takeda’s strategic goals while striving to maintain good working relationship between Takeda and partner. Leadership, Task Force Participation, Upper Management Accountability Interacts directly with research division based on pertinent clinical and development expertise and with TPNA/TPEU to provide knowledge / understanding of market environment in line with status as TGRD scientific content matter expert for assigned compounds. May represent clinical science on multidisciplinary task forces across divisions (e.g. TGRD and TPNA/TPEU/TPC). Lead TGRD internal teams and may lead global cross-functional teams, as appropriate. Hires, manages, mentors, motivates, empowers, develops and retains staff to support assigned activities. Conducts performance reviews and drive goal setting and development planning. EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: MD or internationally recognized equivalent plus 7 years of clinical research experience within the pharmaceutical industry, CRO health-related consulting company, or biomedical/clinical experience within academia (or a combination of afore mentioned). Previous experience successfully leading a clinical development team/matrix team with responsibility for studies in multiple regions. NDA/MAA/Submission experience preferred. Management experience Skills Superior communication, strategic, interpersonal and negotiating skills Ability to proactively predict issues and solve problems Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams Diplomacy and positive influencing abilities Knowledge Therapeutic area knowledge relevant to mechanism of action Preferably with expertise in sleep medicine Regional/global Regulatory requirements GCP/ICH Emerging research in designated therapeutic area TRAVEL REQUIREMENTS: Ability to drive to or fly to various meetings or client sites, including overnight trips. Some international travel may be required. Requires approximately 15 - 25% travel. This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy.

  • Cambridgeport, MA

  • no content

Medical Director, Clinical Science - Solid Tumor (BOSTON)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Medical Director, Clinical Science, Solid Tumor in our Cambridge office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission. OBJECTIVES: The Medical Director leads and drives strategy for the overall global (US/EU/Japan) clinical development taking into consideration the medical, scientific, regulatory and commercial issues for assigned Takeda pipeline compounds. Leads a multi-disciplinary, multi-regional, matrix team through highly complex decisions. This individual has the ultimate responsibility for development decisions assessing and integrating the input from various disciplines to create, maintain, and execute a global clinical development plan that will result in the regulatory approval of the assigned compound in multiple regions. Applies clinical/medical decision making to clinical development issues. This individual interacts with and influences TGRD and TPC senior leadership decision-making for the projects by setting strategic direction. Success or failure directly translates to the ability of TGRD to meet its corporate goals and for Takeda to have future commercial products. ACCOUNTABILITIES: Clinical Development team participation and leadership Leads Global (US/EU/Japan) Development Team managing both the US/EU Development Team and the Japan Development Team for a given product. May lead the US/EU Development Teams and represents Clinical Science on the Global (US/EU/Japan) Development Team to ensure that activities are aligned with the global strategy. Establishes and drives Development Team strategy and deliverables producing the Development Strategy, Clinical Development Plan and Clinical Protocols. Recommends scope, complexity and size, and influence the budget of all aspects of a program. Provides continual critical evaluation of the development strategy to maintain a state-of-the-art development plan that is competitive and consistent with the latest regulatory requirements, proactive identification of challenges, and development of contingency plans to meet them. Responsible for high impact global decisions: monitoring and interpreting data from ongoing internal and external studies, assessing the medical and scientific implications, and making recommendations that impact regional and global development such as “go/no go” decisions or modification of development plans or study designs that may have a significant impact on timelines or product labeling. A significant error in judgment may result in loss of approvability and commercial viability of a product. Synopsis / Protocol Development, Study Execution, & Study Interpretation Drives clinical science activities relating to the preparation / approval of synopses, protocols and the conduct of clinical studies. Serves as an advisor to other clinical scientists involved in these activities, and is accountable for the successful design and interpretation of clinical studies. Presents study conclusions to Management and determine how individual study results impact the overall compound strategy. Interprets data from an overall scientific standpoint as well as within the context of the medical significance to individual patients. Trial Medical Monitoring Responsible for medical monitoring activities, assessing issues related to protocol conduct and/or individual subject safety. Assesses overall safety information for studies and compound in conjunction with Pharmacovigilance. Oversees non-medical clinical scientists with respect to assessment of these issues. Makes final decisions regarding study conduct related to scientific integrity. External Interactions Directs activities involved in interactions with regulatory authorities / agencies and clinical development activities undertaken to establish and maintain strong relationships with key opinion leaders relevant to assigned compounds and therapeutic areas. These responsibilities include leadership roles in meetings with the regulatory organizations or key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g. briefing reports), materials used for meeting presentations, and formal responses to communications received from the regulatory organizations or opinion leaders. Lead roles will also be taken on the incorporation of advice / recommendations received into the design of clinical studies / programs as appropriate; accountable to senior leadership for the successful completion of related objectives. Due Diligence, Business Development and Alliance Projects Responsible for identification and evaluation of potential business development opportunities, conduct due diligence evaluations, and development and negotiation of clinical development plans for potential alliances and or in-licensing opportunities. Assesses scientific, medical, and development feasibility, evaluating strategic fit with overall portfolio, evaluating complete or ongoing clinical trials, assessing regulatory interactions and future development plans, interacting with upper management of potential partner/acquisition companies during DD visits and alliance negotiations, and representing clinical science on internal assessment teams in conjunction with TPNA/TPEU/TPC. Serves as clinical contact point for ongoing alliance projects and interface with partner to achieve Takeda’s strategic goals while striving to maintain good working relationship between Takeda and partner. Leadership, Task Force Participation, Upper Management Accountability Interacts directly with research division based on pertinent clinical and development expertise and with TPNA/TPEU to provide knowledge / understanding of market environment in line with status as TGRD scientific content matter expert for assigned compounds. May represent clinical science on multidisciplinary task forces across divisions (e.g. TGRD and TPNA/TPEU/TPC). Lead TGRD internal teams and may lead global cross-functional teams, as appropriate. Hires, manages, mentors, motivates, empowers, develops and retains staff to support assigned activities. Conducts performance reviews and drive goal setting and development planning. EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: Education/ Experience MD, combined MD/PhD or internationally recognized equivalent plus 5 years of clinical research experience within the pharmaceutical industry, CRO health-related consulting company, or biomedical/clinical experience within academia (or a combination of afore mentioned). Training and Experience in Hematology/ Oncology and/or Medical Oncology especially in solid tumor malignancies is preferred Experience in conducting and/or leading clinical trials involving immune-based therapies and/or antibody-drug conjugates is preferred. Late phase clinical development and NDA/MAA/Submission experience is preferred. Previous experience successfully leading a clinical development team/matrix team with responsibility for studies in multiple regions. Management experience Skills Excellent communication and influencing skills, with the ability to engage, inspire, and influence stakeholders at all levels, including executive management and external partners.Ability to proactively predict issues and solve problems Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams Diplomacy and positive influencing abilities Knowledge Therapeutic area knowledge relevant to mechanism of action Regional/global Regulatory requirements GCP/ICH Emerging research in designated therapeutic area TRAVEL REQUIREMENTS: Ability to drive to or fly to various meetings or client sites, including overnight trips. Some international travel may be required. Requires approximately 15 - 25% travel. Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regar

  • Cambridgeport, MA

  • no content

Senior Director, AIRx Computational Chemistry (BOSTON)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Senior Director, Computational Chemistry Takeda Research is constructing the Discovery Automation & Robotics (DAR) group built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and The Discovery Automation & Robotics (DAR) group. AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI-powered operating models and deliver candidates to the clinic at industry leading speed and success rates. Purpose Reporting to the Head of AIRx, the AIRx Computational Chemist sits at the scientific heart of AIRx's AI-first operating model. This role drives in silico molecular design, leverages predictive models, and applies generative chemistry to power rapid DMTA cycles — directly enabling the speed and precision that define the AIRx incubator In AIRx, computational chemistry is a first-order decision-making function — generative proposals from this role directly shape what gets synthesized, what gets deprioritized, and ultimately what reaches the clinic. The role is deeply hands-on, with a unique opportunity to directly shape candidates that advance to the clinic through close collaboration with the wider AIRx design team. Accountabilities Apply generative AI, structure-based design, free energy perturbation, and predictive ML models to design and prioritize chemical matter Partner closely with Medicinal Chemists to translate computational outputs into actionable synthesis priorities; challenge and be challenged in equal measure Lead and oversee virtual screening campaigns, ADMET predictions, and selectivity assessments to inform and accelerate design decisions Contribute to building and refining AI/ML model training datasets from AIRx experimental outputs Develop and maintain computational workflows that increase team speed and reproducibility Interpret and integrate structural biology data (X-ray, cryo-EM) into computational design strategies Communicate complex computational findings clearly to cross-disciplinary colleagues and governance forums Stay current with advances in generative AI, protein structure prediction, and ML methods; proactively apply new approaches Qualifications & Competencies PhD in computational chemistry, cheminformatics, biophysics, or closely related discipline 12–15 years of drug discovery experience with demonstrated track record of computational impact on programs Proficiency across computational tools: molecular docking, MD simulation, FEP, QSAR/ADMET modeling Strong coding skills (Python required); experience building and deploying ML models in a drug discovery context Experience with structure-based drug design; ability to interpret crystallography or cryo-EM data Experience applying generative AI or large language models to molecular design preferred Collaborative, communicative, and comfortable at the wet/dry scientific interface ADDITIONAL INFORMATION The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $212,000.00 - $333,190.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

  • Cambridgeport, MA

  • no content

Fiber Construction Horizontal Directional Driller (HDD) III (Hiring Immediately)

<font size=2>Overview</font>: <p style=margin: 0px;><span style=font-size: 10.0pt; font-family: 'Helvetica',sans-serif;>At TDS Telecom, connecting people is at the heart of everything we do. We are forward thinkers who leverage cutting-edge fiber internet technology to strengthen communities. We are dedicated to excellence, which drives us to succeed together, creating a better world through meaningful connections. Ready to make an impact?</span></p><p style=margin: 0px;> </p><p style=margin: 0px;><span style=font-family: helvetica; font-size: 10pt;><strong>Join Our Team as an Telecom Horizontal Directional Driller in Meridian, ID!</strong></span></p><p style=margin: 0px;> </p><p style=margin: 0px;><span style=font-family: helvetica; font-size: 10pt;>Ready to roll up your sleeves and bring cutting-edge fiber technology to life? As <strong>Telecom Horizontal Directional Driller (HDD) II</strong><strong>I</strong>, you'll be at the heart of building and maintaining our state-of-the-art PON/fiber network.</span></p><p style=margin: 0px;> </p><p style=margin: 0px;><span style=font-family: helvetica; font-size: 10pt;>From installing buried and aerial fiber facilities to mastering construction equipment like trenchers, backhoes, end loaders, and plows, you'll make a real impact every day. You'll also install, test, troubleshoot, and repair fiber facilities to keep our customers connected. If you love working with your hands, being outdoors, and making a difference in your community, this is the role for you!</span></p><p style=margin-bottom: 0in;> </p><p style=margin-bottom: 0in;><span style=font-family: helvetica; font-size: 10pt;><strong><span style=color: black;>Please note</span></strong><span style=color: black;>: This position may be filled as a Telecom Horizontal Directional Driller II (ID <span>2026-29262</span>) or III (ID <span>2026-29263</span>), based on the candidate's skills and qualifications. Separate job postings outline the minimum requirements for each role. Please review both postings and apply to any level for which you are qualified and interested.</span></span></p><p style=margin-bottom: 0in;> </p><p style=margin-bottom: 0in;><span style=font-family: helvetica; font-size: 10pt;><strong><span style=color: black;>Schedule:</span></strong></span><span style=font-family: helvetica; font-size: 10pt;><strong> </strong></span></p><p style=margin-bottom: 0in;><span style=color: black; font-family: helvetica; font-size: 10pt;>This is a full-time, 40-hour-per-week role with a *flexible schedule.</span></p><p style=margin-bottom: 0in;><span style=color: black; font-family: helvetica; font-size: 10pt;>*Please note that the schedule may vary depending on the specific market.</span></p><p style=margin-bottom: 0in;> </p><p style=margin-bottom: 0in;><span style=font-family: helvetica; font-size: 10pt;><strong><span style=color: black;>Why Join Us?</span></strong></span><span style=font-family: helvetica; font-size: 10pt;><strong> </strong></span></p><p style=margin-bottom: 0in;><span style=color: black; font-family: helvetica; font-size: 10pt;>As a member of our Construction and Service Enablement team at TDS, you’ll play a critical role in building and maintaining cutting-edge fiber optic networks that connect communities nationwide. With over 50 years of experience, TDS is a leader in fiber internet innovation, delivering up to 10 Gigabit speeds to homes and businesses. Join our team and be part of a collaborative environment where your skills in construction, safety, and technology will directly impact the future of connectivity in urban, suburban, and rural areas.</span></p><p style=margin-bottom: 0in;> </p><p style=margin-bottom: 0in;><span style=color: black; font-family: helvetica; font-size: 10pt;><em><span style=font-family: helvetica; font-size: 10pt;><span style=color: black;><span style=color: 000000;> This position may be eligible for relocation assistance. For further information, please contact the Talent Acquisition team. </span></span></span></em></span></p> <font size=2>Responsibilities</font>: <ul><li><span style=font-family: helvetica; font-size: 10pt;><strong>Team Leadership Assistance: </strong>At the direction of the Sr Outside Plant Construction Tech, assist with:</span><ul><li><span style=font-family: helvetica; font-size: 10pt;>Communicating job duties and responsibilities to internal construction crews. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Focusing on crew efficiencies, ensuring assigned tasks are completed. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Training, monitoring, and coaching team members to safely perform assigned tasks with related construction equipment. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Performing quality control inspections of construction crew work. Ensuring safety protocols are enforced.</span></li><li><span style=font-family: helvetica; font-size: 10pt;>Working with foreperson to ensure projects remain on schedule and within budget.</span></li></ul></li><li><p style=margin: 0px;><span style=font-family: helvetica; font-size: 10pt;><strong>General Construction Labor</strong></span></p><ul><li><span style=font-family: helvetica; font-size: 10pt;>Operation of trenchers, backhoes, end loaders, plows, and other excavating equipment used to construct and maintain outside plant cable facilities.</span></li><li><span style=font-family: helvetica; font-size: 10pt;>Operation of Horizontal Directional Drills. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Locate cable and fiber and other utilities as required by construction activity. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Performs landscape restoration after project completion.</span></li></ul></li><li><span style=font-family: helvetica; font-size: 10pt;><strong>Construction Site Organization</strong></span><ul><li><span style=font-family: helvetica; font-size: 10pt;>Engage municipalities, utility companies, suppliers, contractors, and property owners to coordinate project tasks and avoid disputes. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Receive maps and staking sheets and ensure construction project is built. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Review, update, and assist with the recording of GIS, maps, addresses, and as-builds. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Ensure locates are performed on time and prior to team and equipment arriving at the worksite. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Set pedestals, vaults, and handholes along with marking/labeling fiber optic and/or copper facilities. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Coordinate with Sr Outside Plant Construction Tech to ensure availability of materials and equipment. </span></li><li><span style=font-family: helvetica; font-size: 10pt;>Perform the placement of new aerial and buried fiber according to maps, staking sheets, and locate markings.</span></li></ul></li><li><p style=margin: 0px;><span style=font-family: helvetica; f

  • Lauderdale, MS

  • no content

Head of Automated Small Molecule Synthesis (BOSTON)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide. Objective / Purpose: The Research Scientific Director, Head of Automated Small Molecule Synthesis , is based in Cambridge, MA, within the R&D — Research division, specifically supporting Takeda’s Digital Discovery & Development Engine. This full-time Director-level role is instrumental in building and leading the automation of small molecule synthesis for Takeda’s Discovery Automation & Robotics (DAR) initiative to implement highly efficient, AI-integrated DMTA (Design–Make–Test–Analyze) cycles toward rapid and reliable small molecule discovery. The Head of Automated Small Molecule Synthesis leads the strategy, design, and execution of small molecule synthesis using fully automated, robotic platforms to accelerate decision-making across Takeda’s discovery portfolio by quickly and reliably generating compound sets for testing. The role collaborates closely with medicinal chemistry, in-vitro pharmacology, DMPK, data science/AI/computational chemistry, and automation engineering to ensure seamless integration of compound synthesis with AI-driven design, and includes integrating retrosynthetic planning, route design, and advanced chemical reaction miniaturization capabilities. Accountabilities: Define and execute the automation strategy for small-molecule synthesis, aligning platform capabilities with organizational discovery and development goals and the Lab of the Future roadmap. Prioritize and sequence automation investments in equipment, software, and talent based on scientific impact, throughput gains, and cost-to-value ratios. Promote the adoption of digital-first and automated approaches across the research community as a change champion. Establish a closed-loop DMTA vision by integrating robotics, digital data capture, and AI/ML to boost synthesis throughput, reduce cycle times, and enhance decision quality. Design end-to-end automated workflows for reaction scouting, parallel synthesis, scale-out, and purification (e.g., flash/Prep-HPLC) to ensure reproducibility and traceability. Standardize method libraries and digital SOPs, covering reaction templates, purification methods, and analytical routines, to enable rapid and consistent deployment across programs. Continuously evaluate and integrate new technologies such as liquid-handling robotics, continuous flow, microreactors, smart reactors, and generative chemistry tools. Accelerate DMTA cycles through high-throughput experimentation (HTE), parallel synthesis arrays, flow chemistry, and automated purification integrated with ELN/LIMS and scheduling/orchestration systems for efficient, low-touch labs. Establish and refine a vision for fully integrated workflows that encompass compound design, purification, QC data capture, analysis, and sample preparation for testing. Define, track, and report KPIs such as workflow efficiency, data accessibility, and cycle time improvements. Encourage method innovation, including novel reaction classes on automation, greener conditions, and continuous processing. Drive reliability engineering, preventive maintenance, and improvements Integrate EHS, machine safety, and cybersecurity Ensure up-time with scheduled maintenance, spares management, incident handling, and corrective action. Scale workflows from prototype to routine and maintain lab safety and compliance for automated operations. Oversee change control, validation, risk assessment, and conduct drills and post-mortems. Engage externally through contributions to patents, publications, and presentations that highlight platform advancements, and by active participation in consortia and conferences to share knowledge and gain insights to remain at the forefront of best practices. Contribute to data governance practices that promote longitudinal learning across Takeda’s discovery portfolio. Uphold Takeda’s values of Integrity, Fairness, Honesty, and Perseverance in all scientific and operational activities. Education & Competencies (Technical and Behavioral): Expected: Ph.D. in Organic or Medicinal Chemistry (or related field) with 10 years of experience; or M.S. with 16 years of experience; or B.S. with 18 years of experience in pharmaceutical or biotech R&D, including small-molecule discovery. Deep medicinal chemistry knowledge, including SAR, SBDD, cheminformatics, and ADME/PK data interpretation. 10 years building and scaling lab or chemical process automation, and 5 years leading cross-functional R&D teams. Proficiency with automated synthesis platforms, including robotic reaction screening, parallel synthesis, and purification systems. Experience with AI-driven DMTA and autonomous design-make loops and experiment planners. Familiarity with scheduling software, LIMS/ELN, and data pipeline tools used in automated labs. Strong leadership, managing and developing scientific teams at the senior scientist/principal scientist level. Exceptional written and verbal communication, with ability to influence at the Executive Director and VP levels. Demonstrated ability to drive change and transformation in complex, global R&D organizations. ADDITIONAL INFORMATION The position will be based in Cambridge, MA. Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $177,000.00 - $278,080.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

  • Cambridgeport, MA

  • no content

Associate Medical Director, Clinical Science, NS TAU (CAMBRIDGE)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Associate Medical Director in our Neuroscience Therapeutic Area Unit in our Cambridge, MA office. ​ ​At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. ​ ​Here, you will be a vital contributor to our inspiring, bold mission ​ ​ POSITION OBJECTIVES: ​The Associate Medical Director leads and drives strategy for clinical studies within the overall global clinical development for assigned Takeda pipeline compound(s) taking into consideration the medical, scientific, regulatory and commercial issues. Leads or joins multi-disciplinary, multi-regional, matrix team through highly complex decisions. This individual has the responsibility for development decisions assessing and integrating the input from various disciplines to create, maintain, and execute studies within a clinical development plan that will result in the regulatory approval of the compound in multiple regions. Applies clinical/medical decision making to clinical development issues. This individual interacts with and influences Neuroscience Therapeutic Area Unit senior leadership decision-making by contributing to strategic direction. Success or failure directly translates to the ability of R&D to meet its corporate goals and for Takeda to have future commercial products. ​ ​ ACCOUNTABILITIES: ​Clinical team participation and leadership Represents Clinical Science on Study Execution and Clinical Teams and may serve as co-leader of these teams. Supports the Global Project Team to ensure that the clinical team activities are aligned with the global strategy. May act as Global Clinical Lead for an early clinical stage or preclinical program with significant interactions with translational and biomarker colleagues, and preclinical teams. ​Contributes to Global Project and clinical team strategy and deliverables working on the Asset Strategy, Clinical Development Plan, Clinical Protocols and other documents needed for study execution. Recommends scope, complexity and size, and influences the budget of all aspects of a study or program. Ongoing work output will involve continual critical evaluation of the development strategy to maintain a state-of-the-art development plan that is competitive and consistent with the latest regulatory requirements, proactive identification of challenges, and development of contingency plans to meet them. Recommends high impact global decisions. Responsible for monitoring and interpreting data from ongoing internal and external studies, assessing the medical and scientific implications and making recommendations that impact regional and global development such as “go/no go” decisions or modification of development plans or study designs that may have a significant impact on timelines or product labeling. ​ ​Synopsis / Protocol Development, Study Execution, & Study Interpretation Oversees all Clinical Science activities relating to the preparation / approval of Synopses, Protocols and the conduct of clinical studies. Serves as an advisor to other clinical scientists involved in these activities, and be accountable for the successful design and interpretation of clinical studies. ​Interprets data from an overall scientific standpoint as well as within the context of the medical significance to individual patients. Presents study conclusions to Management and determines how individual study results impact the overall compound strategy. ​ ​Trial Medical Monitoring Responsible for medical monitoring activities, assessing issues related to protocol conduct and/or individual subject safety. Assesses overall safety information for studies and compound in conjunction with Pharmacovigilance. Oversees non-medical clinical scientists with respect to assessment of these issues. Makes final decisions regarding study conduct related to scientific integrity. ​ ​External Interactions Directs interactions with key opinion leaders relevant to assigned compounds and therapeutic area. Provides leadership in meetings and negotiations with key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g. briefing reports), materials used for meeting presentations, and formal responses to communications received from the regulatory organizations or opinion leaders. Leads incorporation of advice / recommendations received into the design of clinical studies and programs as appropriate. ​ ​Due Diligence, Business Development and Alliance Projects Responsible for evaluation of potential business development opportunities and conduct of due diligence evaluations assessing scientific, medical and development feasibility, evaluating complete or ongoing clinical trials, and regulatory interactions and future development plans. Contributes to the development and negotiation of clinical development plans for potential alliances and or in-licensing opportunities, interacts with upper management of potential partner/acquisition companies during DD visits and alliance negotiations and represents clinical science on internal assessment teams. For ongoing alliance projects, will interface with partner to achieve Takeda’s strategic goals while striving to maintain good working relationship between Takeda and partner. ​ ​Leadership, Task Force Participation, Upper Management Accountability Interacts with research division and other function based on pertinent clinical and development expertise to provide knowledge / understanding of market environment in line with status as scientific content matter expert for assigned compounds. Represents clinical science and contributes to or leads internal task forces and Therapeutic Area internal teams as well as global cross-functional teams as appropriate. Mentors, motivates, empowers, develops and retains staff to support assigned activities. ​ ​ ​EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: ​ ​Education and experience MD,MD/PhD, or internationally recognized equivalent plus 3 years of clinical research experience within the pharmaceutical industry, CRO health-related consulting company, or biomedical/clinical experience within academia (or a combination of afore mentioned). ​Previous experience successfully leading matrix teams preferred. Previous experience in designing and executing first in human and early proof of concept trials preferred ​Skills ​Superior communication, strategic, interpersonal and negotiating skills ​Ability to proactively predict issues and solve problems ​Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams ​Diplomacy and positive influencing abilities ​Knowledge ​Neurology Therapeutic area knowledge preferred Specialization in Neurology preferred Subspecialty expertise in neuromuscular disease or neurodegenerative disease preferred ​Regional/global Regulatory requirements ​GCP/ICH ​ ​ ​TRAVEL REQUIREMENTS: ​Ability to drive to or fly to various meetings or client sites, including overnight trips. Some international travel may be required. ​Requires approximately –10 - 20% travel. This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy ​ ​Empowering Our People to Shine ​ ​Discover more at takedajobs.com ​ No Phone Calls or Recruiters Please. LI-JV2 Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: USA - MA - Cambridge

  • Cambridgeport, MA

  • no content

Senior Director, AIRx Discovery Biology Lead (BOSTON)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Senior Director, AIRx Discovery Biology Lead Takeda Research is constructing the Discovery Automation & Robotics (DAR) group built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and The Discovery Automation & Robotics (DAR) group. AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI-powered operating models and deliver candidates to the clinic at industry leading speed and success rates. Purpose Biology is the strategic core of every AIRx program — As Discovery Biology Lead, you will set the mechanistic and translational foundation that determines whether a program deserves to advance, guiding the team from target hypothesis to clinical hypothesis with the intellectual authority that only deep disease biology expertise can provide. Responsibilities include directing CRO partners with precision and accountability to generate high-quality, interpretable data that feeds into AI-powered DMTA cycles, and connecting experimental biology to translational strategy and clinical outcomes. The AIRx Discovery Biology Lead combines deep scientific expertise with the agility to thrive in an externalized, AI-powered operating model — leveraging biological depth and pragmatism to direct and integrate biology at speed, while role modeling new ways of working in Discovery Automation & Robotics (DAR) group. Accountabilities Own the disease biology and target validation strategy across the AIRx portfolio; ensure all programs have mechanistic rationale, clear differentiation, and clinical line of sight Define translational biomarker strategies supporting go/no-go decisions and future clinical development Design and provide strategic oversight of CRO-executed in vitro and in vivo biology studies; critically evaluate data packages for scientific quality and decision-readiness Integrate biology data into AI-enabled DMTA cycles alongside medicinal/computational chemists, DMPK, safety, and structural biology Challenge scientific assumptions across the team; ensure biological integrity and mechanistic depth underpin all program decisions Represent biology perspectives at Takeda governance forums; contribute to IND-enabling biology packages Stay current with disease biology and the competitive landscape; proactively inform the team of relevant developments Shape how biology is practiced in the AIRx model — your ways of working here will become the template for Takeda Research’s future operating model Qualifications & Competencies PhD in cell biology, molecular biology, pharmacology, or closely related discipline 12-15 years of drug discovery experience with a strong track record in target validation and disease biology Proven contributions to IND filings; experience supporting IND-enabling biology packages Track record designing and managing externalized CRO biology programs; ability to scope, oversee, and critically interpret study data Ability to connect target biology to clinical hypothesis and translational strategy AI/ML data integration experience; comfortable working with large multi-source datasets Experience in at least one therapeutic area represented across the Takeda Research portfolio Excellent cross-functional collaboration skills; able to operate effectively in a lean, fast-paced team ADDITIONAL INFORMATION The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $212,000.00 - $333,190.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

  • Cambridgeport, MA

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Medical Director, Clinical Science, GI2 TAU (CAMBRIDGE)

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Medical Director, Clinical Science, GI2 TAU in our Cambridge, MA office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission. ACCOUNTABILITIES: Represents Clinical Science on Project or Clinical Teams and may serve as the Clinical Science leader on these teams Supports the Global Project Team to ensure that the clinical team activities are aligned with the global strategy Contributes to the overall Asset Strategy by supporting the development of the Clinical Development Plan, leads the development of Clinical Protocols and other documents needed for CDP and study execution and regulatory submissions. Recommends scope, complexity and size, and influences the budget of all aspects of a study Ongoing work output will involve continual critical evaluation of the development strategy to maintain a state-of-the-art development plan that is competitive and consistent with the latest regulatory requirements, proactive identification of challenges, and development of contingency plans to meet them. Responsible for high impact global decisions: monitoring and interpreting data from ongoing internal and external studies, assessing the medical and scientific implications and making recommendations that impact regional and global development such as “go/no go” decisions or modification of development plans or study designs that may have a significant impact on timelines or product labeling. A significant error in judgment may result in loss of approvability and/or commercial viability of a product. Synopsis / Protocol Development, Study Execution, & Study Interpretation Drives Clinical Science department activities relating to the preparation/ approval of Synopses, Protocols and the conduct of clinical studies. Serves as an advisor to other clinical scientists involved in these activities and is accountable for the successful design and interpretation of clinical studies. Presents study conclusions to Management and determines how individual study results impact the overall compound strategy. Interprets data from an overall scientific standpoint as well as within the context of the medical significance to individual patients. Trial Medical Monitoring Responsible for medical monitoring activities, assessing issues related to protocol conduct and/or individual subject safety. Assesses overall safety information for studies and compound in conjunction with Pharmacovigilance. Oversees non-medical clinical scientists with respect to assessment of these issues. Makes final decisions regarding study conduct related to scientific integrity External Interactions Directs interactions with key opinion leaders relevant to assigned compounds and therapeutic area. Provides leadership in meetings and negotiations with key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g. briefing reports), materials used for meeting presentations, and formal responses to communications received from the regulatory organizations or opinion leaders Leads incorporation of advice/recommendations received into the design of clinical studies and programs as appropriate. Directs activities involved in interactions with regulatory authorities/agencies and clinical development and key opinion leaders relevant to assigned compounds. Provides leadership and serves as an advisor to the other clinical scientists engaged in these activities and, in the context of these responsibilities, will be accountable to senior leadership for the successful completion of related objectives. Due Diligence, Business Development and Alliance Projects Responsible for identification and evaluation of potential business development opportunities, conducts due diligence evaluations and development and negotiation of clinical development plans for potential alliances and or in-licensing opportunities. Assesses scientific, medical, and development feasibility, evaluating strategic fit with overall portfolio, evaluating complete or ongoing clinical trials, assessing regulatory interactions and future development plans., interacting with upper management of potential partner/acquisition companies during DD visits and alliance negotiations, and representing clinical science on internal assessment teams. Serves as clinical contact point for ongoing alliance projects and interfaces with partner to achieve Takeda’s strategic goals while striving to maintain good working relationship between Takeda and partner. Provides guidance to clinical scientists who are involved in some of these activities. Leadership, Task Force Participation, Upper Management Accountability Interacts directly with research division based on pertinent clinical and development expertise. May represent clinical science on multidisciplinary task forces across the organization or external to the company. May lead global cross-functional teams as appropriate. Hires, manages, mentors, motivates, empowers, develops and retains staff to support assigned activities. EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: MD or internationally recognized equivalent plus 5 years of clinical research experience within the pharmaceutical industry, CRO health-related consulting company, or biomedical/clinical experience within academia (or a combination of afore mentioned). Subspecialty in Hepatology or Immunology highly preferred. Experience and knowledge of alpha-1 antitrypsin deficiency a plus. Phase 3 Clinical Trial experience preferred Previous experience successfully leading a clinical development team/matrix team with responsibility for studies in multiple regions. NDA/MAA/Submission and launch experience preferred Management experience preferred Skills Superior communication, strategic, interpersonal and negotiating skills Ability to proactively predict issues and solve problems Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams Diplomacy and positive influencing abilities Knowledge Therapeutic area knowledge relevant to mechanisms of action of compounds in remit Regional/global Regulatory requirements GCP/ICH Emerging research in designated therapeutic area Travel requirements • Ability to drive to or fly to various meetings or client sites, including overnight trips. Some international travel may be required. Requires approximately 15 - 25% travel This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy. Discover more at takedajobs.com No Phone Calls or Recruiters Please LI-JV2 Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: USA - MA - Cambridge U.S. Base Salary Range: $237,200.00 - $372,790.00 The estimated salary range reflects an anticipated r

  • Cambridgeport, MA

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