Principal Mechanical Engineer II, Early Research and Development
About Us A healthier future drives us to innovate, continuously advance science, and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love is what makes us Client. At Client, we are working to make next-generation sequencing simple and accessible for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to Client sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow. Role Overview Our Systems Technology Group, a part of Client Sequencing Solutions, is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking a Principal Mechanical Engineer to lead the mechanical design, development, characterization, and integration of cutting-edge sequencing systems. This is a hands-on role for a multidisciplinary expert focused on solving the core mechanical challenges at the heart of our next-generation platforms. You will be responsible for concepting, designing, building, and testing Client electro-mechanical, pneumatic, thermal, and fluidic solutions that ensure the ultimate performance, reliability, and longevity of our systems. Core Responsibilities Lead the end-to-end mechanical design and development of mechanical sub-systems including electro-mechanical, pneumatic, fluidic, and thermal components. Collaborate with engineers from other disciplines (electrical, consumables, materials) to define and manage all critical technical interfaces for your module. Develop Client mechanisms for automated reagent and flow cell loading, clamping, and sealing, ensuring reliability over repeated use. Architect and design thermal control systems, including the specification and integration of heating/cooling elements, sensors, condensation control, and heat management. Partner with internal and external simulation experts to guide and validate CFD, thermal, and optical models, using empirical data to refine designs. Serve as the primary technical expert for your sub-system during integration, verification, and troubleshooting activities, working directly with the Systems Integration team. Lead cross-functional design reviews, driving alignment and resolving technical trade-offs between mechanical design, consumables, materials, and assay requirements. Drive the technical execution for sub-systems, manage timelines for your design deliverables, and contribute to the overall project plan. Create and maintain all design documentation for your sub-systems, including detailed CAD models, drawings, and specifications. Contribute to the technical strategy for the future integrated system, providing data-driven recommendations on architecture and technology choices based on your sub-system's performance. Present technical progress, data, and design trade-offs to the broader project team and key stakeholders, clearly articulating the rationale and impact of engineering decisions. Who You Are Required: PhD in Mechanical Engineering, Bioengineering, or a related discipline with at least 3 years of relevant industry experience; or a Master's degree with at least 4 years of relevant industry experience; or a Bachelor's degree with at least 7 years of relevant industry experience. Demonstrated deep, hands-on expertise in the design, development, and testing of complex mechanical, electro-mechanical, and pneumatic systems, preferably for life science or diagnostic instrumentation. Hands-on expertise in thermal management and the design of precision temperature control systems. Experience developing fluidics systems and their interfaces including pumps, valves, tubing, sensors, and material selection. Strong proficiency in 3D CAD software (e.g., SolidWorks) for detailed design and the creation of manufacturing drawings. Expertise designing components for a variety of manufacturing processes (e.g., machining, injection molding, 3D printing). Creative and resourceful problem-solver, with the ability to troubleshoot complex issues at the interface of hardware, software, and chemistry. Proficient with common machine shop tools, as well as test and measurement equipment; proficient with rapid prototyping technology such as 3D printers, laser cutters, CNC mills/lathes, etc. Demonstrated level of proficiency with Python, LabVIEW, or similar tools for device control and data acquisition. Preferred: Demonstrated ability to lead technical projects and mentor junior engineers, providing clear guidance and delegating tasks to achieve project goals. Experience using simulation tools (CFD, FEA) to guide design decisions. Previously worked on the development of next-generation sequencing (NGS) or other genomics instrumentation. Experience working in a regulated product development environment. Strong interpersonal and communication skills with the ability to communicate technical knowledge in a clear and understandable manner, especially to non-experts; excel at problem-solving skills and the ability to work under ambiguous situations. Excellent organizational skills, including the ability to efficiently evaluate, prioritize and handle multiple changing projects and priorities; complete work in a timely, accurate and thorough manner. This is an onsite position. Interview Process Phone Interview In-person Interviews and Presentation (Candidate would need to do a bio presentation of skill sets etc.) Benefits Nesco Resource offers a comprehensive benefits package for our associates, which includes a MEC (Minimum Essential Coverage) plan that encompasses Medical, Vision, Dental, 401K, and EAP (Employee Assistance Program) services. Equal Employment Opportunity Nesco Resource provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.
