Senior Director, Drug Substance Manufacturing

Senior Director, Drug Substance Manufacturing Join to apply for the Senior Director, Drug Substance Manufacturing role at BioSpace Company Overview Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. Role Summary The Senior Director, Drug Substance Manufacturing is responsible for leading GMP drug substance manufacturing, process performance qualification (PPQ), ensuring commercial supply, and overseeing all CMC activities related to Fab-oligonucleotide conjugates (drug substance). This role includes strategic vendor management for commercial drug substance production and coordination of external development and manufacturing activities with contract development and manufacturing organizations (CDMOs), contract testing laboratories (CTLs), and other key suppliers. This role works closely with key stakeholders including Development, R&D, Clinical, Regulatory Affairs, Project Management, and corporate leadership to define and build the capabilities required to effectively manage Dyne’s complex clinical supply chain and support eventual launch and commercialization efforts. This role is based in Waltham, MA. Primary Responsibilities Responsible for bioconjugation activities including validation, characterization, scale-up, clinical and commercial manufacturing. Establish and manage contracts, supply agreements and CDMOs Oversee suppliers and vendors involved in materials planning, inventory control, logistics, distribution to ensure that batch manufacturing is completed on a timely basis Work closely with CMC Technical Development to support bioconjugation improvement activities and enhance the tech transfer process Support QA compliance with cGMPs, cGLPs and guidance for clinical trial materials Prepare and review CMC documentation for biologic INDs and BLAs and support FDA and EMEA interactions Support the development of regulatory CMC documentation and partner due diligence Work with partner organizations as necessary to ensure that timelines are met, milestones and products are delivered on schedule, and any excursions, deviations, investigations, and CAPAs are initiated, addressed and closed within target timeframes Provide patents and creative ideas to provide protection or creation of new or better products or processes Education & Skills Requirements Bachelor’s degree in biology, biochemistry, chemistry, or a related scientific field required; advanced degree preferred. Minimum 12 years of experience in biopharmaceutical manufacturing, including CMC management and oversight of complex development programs. Proven expertise in bioconjugates, as well as strong knowledge of biologics and small molecule manufacturing, materials management, quality control/assurance, and CMC regulatory requirements. Demonstrated experience in leading contract manufacturing and managing external partners such as CDMOs and CTLs. Comprehensive experience with CMC regulatory submissions across all phases of development, ideally including post-approval activities, global regulatory interactions, and negotiations with health authorities on CMC issues related to biologic APIs. Strong understanding of processes and systems supporting biopharmaceutical development, with the ability to challenge current practices and drive continuous improvement. Exceptional leadership and interpersonal skills, including the ability to influence without authority, motivate teams, and collaborate effectively across functions and organizational levels. Highly organized with demonstrated ability to prioritize workload, manage multiple programs in a fast-paced, deadline-driven environment, and consistently deliver on objectives. Skilled in strategic thinking and problem-solving, with the ability to evaluate options, identify pros and cons, and implement creative solutions. Excellent communication and negotiation skills, capable of building consensus and achieving win-win outcomes across diverse stakeholders. Self-directed and adaptable, able to work independently with limited guidance in a complex and evolving environment. Salary Pay Range: $217,280 - $266,750 USD Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. J-18808-Ljbffr

Director of Business Development

4 days ago Be among the first 25 applicants Direct message the job poster from Theron Solutions Overview Business Development Director — Boston, MA or Hartford, CT; Full-time, Hybrid Responsibilities Proactive-demand generation through Consultative Selling for assigned logos Grow and expand company's presence within Banking/Financial Services/Insurance firms in the Eastern and Central US locations. Shape new business opportunities and large deals for Banking/Financial Services/Insurance vertical in US East and Central locations Understand Insurance Industry and associated business and technological trends Establish cross functional CXO relationships and generate overall momentum for identified accounts. Achieve growth targets, originate deals, acquire new logos, expand footprint within assigned existing clients Qualifications Min 12-15 years of overall selling experience with majority experience in Insurance vertical Must have worked in a leading IT services/consulting firm with experience in collaborating across global teams. Direct industry experience of working in Financial Services and/or Mortgage business Demonstrated track record of increasing revenue through generation of leads Strong communication and negotiation skills Our client is an Equal Opportunity Employer, committed to a workplace free from discrimination and harassment. Employment decisions are based on business needs, job requirements, and individual qualifications without regard to race, color, religion, gender, age, disability, sexual orientation, gender identity, marital status, military service, genetic information, or any other status protected by law. Details Seniority level: Director Employment type: Full-time Job function: Sales, Business Development, and Finance Industries: IT Services and IT Consulting and Business Consulting and Services Referrals increase your chances of interviewing at Theron Solutions by 2x Inferred from the description for this job Medical insurance Vision insurance 401(k) Pension plan Paid maternity leave Disability insurance Get notified about new Director of Business Development jobs in Greater Boston . We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. J-18808-Ljbffr

Frontend Software Engineer

About HeyGen At HeyGen, our mission is to make visual storytelling accessible to all. Over the last decade, visual content has become the preferred method of information creation, consumption, and retention. But the ability to create such content, in particular videos, continues to be costly and challenging to scale. Our ambition is to build technology that equips more people with the power to reach, captivate, and inspire audiences. Learn more at www.heygen.com. Visit our Mission and Culture doc here. Position Summary HeyGen, a trailblazing AI-powered platform transforming the landscape of video creation, is seeking a talented Frontend Engineer to join our dynamic team. As a Frontend Engineer at HeyGen, you will play a crucial role in shaping the future of our cutting-edge platform, focusing primarily on the development and enhancement of its user-facing components. Key Responsibilities Frontend Development : Design, implement, and maintain high-quality frontend features for the HeyGen platform. Ensure optimal performance, scalability, and responsiveness of the user interface. Collaboration : Work closely with UX/UI designers to translate designs and wireframes into high-quality code. Collaborate with backend engineers and product managers to ensure seamless integration of frontend and backend components. User Experience Focus : Prioritize user experience in all development efforts. Conduct user testing and feedback sessions to refine and improve the platform interface. Maintenance & Optimization : Monitor frontend performance, identify and resolve issues. Stay updated with emerging frontend technologies and best practices to continually enhance the platform's user interface. Qualifications Experience with responsive and adaptive design principles. Familiarity with RESTful API integration. Understanding of version control systems like Git. Excellent problem-solving skills and attention to detail. Prior experience in SaaS and AI product development is a plus. What HeyGen Offers Competitive salary and benefits package. Dynamic and inclusive work environment focused on innovation and creativity. Opportunities for professional growth and skill development. Collaborative culture that values teamwork and employee input. Access to state-of-the-art technologies and tools. Salary Range $180,000 – $240,000 annually Please note that the salary information is a general guideline only. HeyGen considers factors such as scope and responsibilities of the position, candidate's work experience, education/training, key skills, and internal equity, as well as location, market and business considerations when extending an offer. As part of our total rewards package, HeyGen offers comprehensive benefits including a 401k plan, health benefits, generous PTO, a parental leave program and emotional health resources. HeyGen is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Join us at HeyGen and be part of a team that's reshaping the world of video creation through innovative technology! Apply for this job J-18808-Ljbffr

Associate Director - Corporate Finance - Turnaround & Restructuring

Associate Director - Corporate Finance - Turnaround & Restructuring Join to apply for the Associate Director - Corporate Finance - Turnaround & Restructuring role at BRG Associate Director - Corporate Finance - Turnaround & Restructuring 1 day ago Be among the first 25 applicants Join to apply for the Associate Director - Corporate Finance - Turnaround & Restructuring role at BRG We do Consulting Differently We do Consulting Differently The BRG Corporate Finance practice specializes in providing strategic, operational, and financial advice to private equity firms, management teams, boards of directors, investors, hedge funds, and other lenders or companies that are either underperforming or in transition. The BRG Corporate Finance practice has in-depth experience across a wide range of industries and markets, including but not limited to retail, consumer products, financial services, healthcare, energy and technology. Across sectors, BRG has experienced professionals who understand the challenges clients face — making it well-equipped to help solve clients’ issues. Our Five Core Service Offerings Include Turnaround & Restructuring (T&R) Transaction Advisory (TA) Finance Excellence (FE) Private Equity PortCo Services (PEPS) Transaction & Valuation Opinions (VAL) Skills The BRG Turnaround & Restructuring practice is seeking to add professionals due to client demand and market opportunities. The ideal candidate should be prepared to work in a team-oriented environment on a diverse range of turnaround advisory assignments. Articulating findings and recommendations around the key financial, business issues, and value drivers are critical components for this position. The ideal candidate will have skills in the following areas: Three-statement financial modeling, including scenario planning Financial planning & analysis 13-week cash flow modeling Chapter 11 process Transactions, including sale of assets or businesses Responsibilities Support the day-to-day activities of BRG Corporate Finance – Turnaround & Restructuring client service teams on engagements. Manage the junior team on multiple tasks across a consulting engagement including modeling and client presentations. Utilize finance, accounting, and analytical skills to perform and oversee tasks including: 13-week cash flow models, 3-statement models, and pro-forma scenario models. Demonstrate the ability to work in a team environment; collaborate with T&R and BRG experts, professionals from other firms, and client contacts to achieve engagement objectives. Assist in preparation of reports, written analyses, presentations, and other client deliverables. Participate in the development of a fast-growing, entrepreneurial consulting practice including assisting in marketing, client pitches, and product and practice development. Open and ready to expand your network with clients to become a trusted, reputable advisor. Qualifications Bachelors degree or degree equivalent in Business, Accounting/Finance, Management, Engineering, Economics, Mathematics, or related field; 9 years of work experience, ideally in a consulting or professional services environment; Expertise in financial modeling and analysis, including constructing and understanding 3-statement financial models, cash flows, and scenario analyses; Ability to manage and analyze large volumes of financial and operational data; Excellent written and oral communication skills and a demonstrated ability to interact with junior and senior team members, senior management, and other stakeholders or professionals; Strong problem solving and project management skills; CFA, CPA (or equivalent), or technical/GAAP accounting expertise is a plus Advanced in Microsoft Excel, PowerPoint, Word; Familiarity with financial research tools (e.g., Capital IQ, Bloomberg, etc.); and Willingness to travel as needed. Candidate must be able to submit verification of their legal right to work in the United States, without company sponsorship. PM22 About BRG BRG combines world-leading academic credentials with world-tested business expertise purpose-built for agility and connectivity, which sets us apart—and gets you ahead. At BRG, our top-tier professionals include specialist consultants, industry experts, renowned academics, and leading-edge data scientists. Together, they bring a diversity of proven real-world experience to economics, disputes, and investigations; corporate finance; and performance improvement services that address the most complex challenges for organizations across the globe. Our unique structure nurtures the interdisciplinary relationships that give us the edge, laying the groundwork for more informed insights and more original, incisive thinking from diverse perspectives that, when paired with our global reach and resources, make us uniquely capable to address our clients’ challenges. We get results because we know how to apply our thinking to your world. At BRG, we don’t just show you what’s possible. We’re built to help you make it happen. BRG is proud to be an Equal Opportunity Employer. Our hiring practices provide equal opportunity for employment without regard to race, religion, color, sex, gender, national origin, age, United States military veteran status, ancestry, sexual orientation, marital status, family structure, medical condition including genetic characteristics or information, veteran status, or mental or physical disability so long as the essential functions of the job can be performed with or without reasonable accommodation, or any other protected category under federal, state, or local law. Seniority level Seniority levelMid-Senior level Employment type Employment typeFull-time Job function Job functionFinance and Sales IndustriesBusiness Consulting and Services Referrals increase your chances of interviewing at BRG by 2x Get notified about new Associate Director Corporate Finance jobs in Boston, MA . Senior Associate, Corporate Finance & StrategySenior Finance Manager, Corporate Development Finance Boston, MA $164,600.00-$245,000.00 2 weeks ago Senior Associate Director of Athletics - Finance and AdministrationSenior Associate - Corporate Finance - Turnaround & RestructuringSenior Associate - Corporate Finance - Transaction Advisory Boston, MA $80,000.00-$135,000.00 2 days ago Assistant Director of Research Administration and Finance We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. J-18808-Ljbffr

Senior Product Manager, Shop Advertiser Experience - Global Monetization Product and Technology[]

Senior Product Manager, Shop Advertiser Experience – Global Monetization Product and Technology (Seattle) 2 weeks ago Be among the first 25 applicants About the Team We are seeking an experienced Product Manager to lead the development and optimization of our advertiser experience for Shop Ads campaigns within TikTok Ads Manager. This role is pivotal in building holistic e‑comm ad solutions that make online advertising more accessible and effective for sellers of all sizes. Responsibilities Lead the development and optimization of Shop Ads advertiser experience within TikTok Ads Manager for performance ads campaigns. Implement intuitive UI/UX solutions for advertisers to create, manage, and analyze Shop Ads campaigns. Own the roadmap and strategy for campaign management features in Ads Manager and define and prioritize product requirements in alignment with business goals and customer needs. Collaborate with cross‑functional teams and internal stakeholders to identify challenges, define product strategies, and set objectives that align with the needs of performance advertisers. Leverage customer feedback, user research, and data analytics to identify opportunities for growth and continuous improvement in the advertiser facing experiences. Stay up-to-date with ad tech trends and emerging technologies, applying this knowledge to keep TikTok at the forefront of advertising solutions. Track and analyze key product metrics to inform product decisions and drive iterative improvements to the ads platform. Qualifications Minimum Qualifications: BA/BS degree. 5 years of experience as a Product Manager, managing full product cycles, integrating customer feedback, and driving prioritization. 2 years of experience building and launching ad interfaces or platform products, in addition to overall experience. Strong problem‑solving and analytical skills, with the ability to use data to guide product decisions and improve performance. Proven ability to collaborate cross‑functionally with engineering, design, data science, and other teams. Excellent communication skills, capable of articulating complex product concepts to both technical and non‑technical stakeholders. Bilingual in Mandarin for global cross‑functional collaboration with Chinese stakeholders. (high proficiency, oral and written) Preferred Qualifications: Strong knowledge of the online advertising ecosystem, including ad creation, optimization, bidding and TikTok Shop ecosystem. Experience with TikTok Ads Manager or other major ad platforms and/or experience with shopping platforms. About TikTok TikTok is the leading destination for short‑form mobile video. At TikTok, our mission is to inspire creativity and bring joy. TikTok’s global headquarters are in Los Angeles and Singapore, and we also have offices in New York City, London, Dublin, Paris, Berlin, Dubai, Jakarta, Seoul, and Tokyo. Why Join Us Inspiring creativity is at the core of TikTok’s mission. Our innovative product is built to help people authentically express themselves, discover and connect – and our global, diverse teams make that possible. Together, we create value for our communities, inspire creativity and bring joy – a mission we work towards every day. We strive to do great things with great people. We lead with curiosity, humility, and a desire to make impact in a rapidly growing tech company. Every challenge is an opportunity to learn and innovate as one team. We’re resilient and embrace challenges as they come. By constantly iterating and fostering an "Always Day 1" mindset, we achieve meaningful breakthroughs for ourselves, our company, and our users. When we create and grow together, the possibilities are limitless. Join us. Diversity & Inclusion TikTok is committed to creating an inclusive space where employees are valued for their skills, experiences, and unique perspectives. Our platform connects people from across the globe and so does our workplace. At TikTok, our mission is to inspire creativity and bring joy. To achieve that goal, we are committed to celebrating our diverse voices and to creating an environment that reflects the many communities we reach. We are passionate about this and hope you are too. TikTok Accommodation TikTok is committed to providing reasonable accommodations in our recruitment processes for candidates with disabilities, pregnancy, sincerely held religious beliefs or other reasons protected by applicable laws. If you need assistance or a reasonable accommodation, please reach out to us at https://tinyurl.com/RA-request Job Information 【For Pay Transparency】Compensation Description (Annually) The base salary range for this position in the selected city is $156,864 - $296,020 annually. Compensation may vary outside of this range depending on a number of factors, including a candidate’s qualifications, skills, competencies and experience, and location. Base pay is one part of the Total Package that is provided to compensate and recognize employees for their work, and this role may be eligible for additional discretionary bonuses/incentives, and restricted stock units. Benefits may vary depending on the nature of employment and the country work location. Employees have day one access to medical, dental, and vision insurance, a 401(k) savings plan with company match, paid parental leave, short‑term and long‑term disability coverage, life insurance, wellbeing benefits, among others. Employees also receive 10 paid holidays per year, 10 paid sick days per year and 17 days of Paid Personal Time (prorated upon hire with increasing accruals by tenure). The Company reserves the right to modify or change these benefits programs at any time, with or without notice. For Los Angeles County (unincorporated) Candidates: Qualified applicants with arrest or conviction records will be considered for employment in accordance with all federal, state, and local laws including the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. Our company believes that criminal history may have a direct, adverse and negative relationship on the following job duties, potentially resulting in the withdrawal of the conditional offer of employment: Interacting and occasionally having unsupervised contact with internal/external clients and/or colleagues; Appropriately handling and managing confidential information including proprietary and trade secret information and access to information technology systems; Exercising sound judgment. Seniority level Mid‑Senior level Employment type Full‑time Job function Product Management and Marketing Industries Technology, Information and Internet J-18808-Ljbffr

Senior DevOps Engineer (Ref: 194285)

We are collaborating with our client, an innovative fintech startup headquartered in the Bay Area, which focuses on delivering real-time card data primarily aimed at B2B software firms. Established as a spin-out in early 2024 and launching their product by the summer of that year, this organization is at a pivotal growth juncture, experiencing an expanding customer base and ambitious future initiatives. With the support of notable investors including Nica Partners, QED Investors, RBC, and Visa, this organization is championing advancements in card issuance technology. Their team of 20 passionate professionals is seeking exceptional engineers to aid in scaling their operations. Job Description Senior DevOps Engineer (L1): steering the evolution of infrastructure and serverless architecture within an AWS framework, extensively utilizing Lambda. The ideal candidate will spearhead serverless migrations while upholding security protocols essential for the fintech and payments domain, particularly regarding PCI compliance. Key Responsibilities Design and implement serverless infrastructure using AWS Lambda and associated services. Lead the serverless migration process and help define the infrastructure roadmap. Ensure compliance with PCI standards and establish security best practices throughout the infrastructure. Manage and optimize SQL-based databases hosted on AWS. Collaborate with teams to advance the organization's Kubernetes capabilities as they grow their microservices architecture. Work collaboratively with engineering teams to enhance deployment pipelines and improve the developer experience. Engage in a hybrid work model, requiring in-office presence on Tuesdays, Wednesdays, and Thursdays. Requirements Required: A minimum of senior-level (L1) experience in DevOps or Infrastructure engineering. In-depth knowledge of AWS, particularly Lambda and serverless architectures. A strong background in security practices, especially regarding PCI compliance for infrastructure. Experience with SQL-based database management. Familiarity with the fintech or payments industry is essential. Knowledge of the card issuance sector and experience with payment networks, ideally including Mastercard. Startup experience with a proven ability to deliver quick and effective solutions. A willingness to relocate to or already residing in the Bay Area. Preferred: Experience with Kubernetes. Expertise in microservices architecture. Prior experience at organizations such as Marqeta, Plaid, Ramp, or Brex. Experience working with payment networks. A competitive compensation package comprising both salary and equity, ensuring alignment with the best talent available. A 4% matching contribution for the 401(k) plan. Comprehensive medical and dental insurance managed through Rippling. Regular off-site events throughout the year in diverse locations across the US and Europe, including frequent trips to California and New York. Exclusive company merchandise. A hybrid work structure requiring three days of on-site work. Seniority level Mid-Senior level Employment type Full-time Job function Information Technology and Engineering Industries Financial Services and Software Development J-18808-Ljbffr

Managing Director

Hobbs Madison is a leading consulting firm dedicated to bridging the gap between business strategy and technology execution. We combine deep technical and management expertise to solve complex challenges, enhance capabilities, and drive competitive growth. Our clients include some of the largest banking, insurance and investment firms in the United States. The Managing Director is responsible for the leadership, growth, and performance of Hobbs Madison. This role sets strategic direction, drives revenue, oversees client delivery, and ensures operational excellence across the firm. This position partners with executive leadership to define priorities, build scalable infrastructure, and position the company for long term profitability and market relevance. This leader is accountable for financial performance, client satisfaction, business development, and brand reputation. They will ensure the organization delivers high quality consulting services to financial institutions while maintaining disciplined operations, strong culture, and sustainable growth. Success in this role requires strong financial acumen, strategic thinking, and the ability to scale a consulting organization with structure and accountability. This is a full-time, remote role with occasional travel required for client meetings, industry events, and relationship development. Key Responsibilities Define and execute Hobbs Madison’s strategic vision Lead business development efforts and maintain executive client relationships Drive revenue growth and margin performance Oversee pipeline management and revenue forecasting Ensure high quality consulting delivery and client satisfaction Monitor project performance, utilization, and resource allocation Own P and L performance and budget accountability Review financial reporting and key performance metrics Implement scalable processes across operations and delivery Develop and retain high performing leaders, consultants and subject matter experts Strengthen brand presence and industry positioning Manage risk, compliance, and contractual oversight Requirements 10 years of Director level experience in a consulting environment for financial services, including Banks, Credit Unions, Investment Firms and Insurance Firms Proven experience managing full P and L responsibility Demonstrated success in business development and revenue growth Experience leading and scaling teams Strong financial acumen and performance management skills Bachelor’s degree in Business, Finance, Marketing, or related field required; MBA is a plus. About You Strong experience working with C‑Suite executives and senior decision makers in financial institutions. You operate with ownership and full accountability for results You drive growth while protecting profitability and quality You build long-term executive relationships You make disciplined decisions based on financial and operational data You set high standards and hold teams accountable You balance long term strategy with day-to-day execution Willingness to travel occasionally for client meetings and events. You lead with clarity, structure, and consistency J-18808-Ljbffr